Stocks·NASDAQ:MDGL

Madrigal Pharmaceuticals (MDGL)

OverviewFinancialsOwnersFilings
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Revenue, last 12 months$1.43B+93% vs. a year before
Free cash flow, last 12 months-$169MBurning cash
Cash and short-term investments$961MDebt: $341M
Shares outstanding, past year+2.3%23.2M shares now
Cash runway (my math)68 monthsAt $42.2M burned a quarter

Cash runway: about 68 months. Madrigal Pharmaceuticals had $961M in cash and short-term investments on Sep 30, 2026 and burned $169M of free cash flow over the 12 months before that, about $42.2M a quarter. Divide one by the other and that's the runway, if nothing changes.

My math, not the company's. It doesn't count money raised after Sep 30, 2026 (check the Filings tab for offerings), credit lines, or plans to cut spending.

Revenue by year
2017: $020172018: $020182019: $020192020: $020202021: $020212022: $020222023: $020232024: $180M20242025: $958M2025$958M
Show the numbers
Revenue by year
2017$0
2018$0
2019$0
2020$0
2021$0
2022$0
2023$0
2024$180M
2025$958M
Revenue by quarter calendar quarter the period ended in
Q4 23: $0Q1 24: $0Q1 24Q2 24: $14.6MQ3 24: $62.2MQ3 24Q4 24: $103MQ1 25: $137MQ1 25Q2 25: $213MQ3 25: $287MQ3 25Q4 25: $321MQ1 26: $311MQ1 26Q2 26: $364MQ3 26: $431MQ3 26$431M
Show the numbers
Revenue by quarter
Q4 23$0
Q1 24$0
Q2 24$14.6M
Q3 24$62.2M
Q4 24$103M
Q1 25$137M
Q2 25$213M
Q3 25$287M
Q4 25$321M
Q1 26$311M
Q2 26$364M
Q3 26$431M
Operating income (loss) by year profit from the business before interest and taxes
2016: -$25.2M20162017: -$32.1M20172018: -$40.7M20182019: -$95M20192020: -$207M20202021: -$242M20212022: -$294M20222023: -$380M20232024: -$498M20242025: -$300M2025-$300M
Show the numbers
Operating income (loss) by year
2016-$25.2M
2017-$32.1M
2018-$40.7M
2019-$95M
2020-$207M
2021-$242M
2022-$294M
2023-$380M
2024-$498M
2025-$300M
Free cash flow by year cash from operations minus spending on buildings and equipment
2016: -$17.6M20162017: -$22.4M20172018: -$25.5M20182019: -$41.8M20192020: -$158M20202021: -$184M20212022: -$225M20222023: -$326M20232024: -$457M20242025: -$190M2025-$190M
Show the numbers
Free cash flow by year
2016-$17.6M
2017-$22.4M
2018-$25.5M
2019-$41.8M
2020-$158M
2021-$184M
2022-$225M
2023-$326M
2024-$457M
2025-$190M
Cash vs. debt

Cash and short-term investmentsDebt

2016 · Cash and short-term investments: $40.5M20162017 · Cash and short-term investments: $192M20172018 · Cash and short-term investments: $484M20182019 · Cash and short-term investments: $439M20192020 · Cash and short-term investments: $284M20202021 · Cash and short-term investments: $270M2021 · Debt: $020212022 · Cash and short-term investments: $359M2022 · Debt: $69.7M20222023 · Cash and short-term investments: $634M2023 · Debt: $115M20232024 · Cash and short-term investments: $926M2024 · Debt: $118M20242025 · Cash and short-term investments: $984M2025 · Debt: $340M2025
Show the numbers
Cash and short-term investmentsDebt
2016$40.5Mn/a
2017$192Mn/a
2018$484Mn/a
2019$439Mn/a
2020$284Mn/a
2021$270M$0
2022$359M$69.7M
2023$634M$115M
2024$926M$118M
2025$984M$340M
Stock pay vs. buybacks

Stock-based pay to employeesSpent buying back shares

2020 · Stock-based pay to employees: $20.7M2020 · Spent buying back shares: $020202021 · Stock-based pay to employees: $26.9M2021 · Spent buying back shares: $020212022 · Stock-based pay to employees: $31.6M2022 · Spent buying back shares: $020222023 · Stock-based pay to employees: $49.7M2023 · Spent buying back shares: $020232024 · Stock-based pay to employees: $79.9M2024 · Spent buying back shares: $020242025 · Stock-based pay to employees: $98.1M2025 · Spent buying back shares: $02025
Show the numbers
Stock-based pay to employeesSpent buying back shares
2020$20.7M$0
2021$26.9M$0
2022$31.6M$0
2023$49.7M$0
2024$79.9M$0
2025$98.1M$0

If buybacks are smaller than stock pay, the buyback isn't shrinking the share count; it's soaking up shares handed to employees.

Compare MDGL with other stocks →

From the company's own SEC filings via SEC EDGAR, latest period ended Sep 30, 2026. Numbers can be restated later. Not investment advice.

Dilution

Shares outstanding adjusted for the
Feb 2023: 18.1MMay 2023: 18.3MMay 2023Aug 2023: 18.5MNov 2023: 19.7MNov 2023Feb 2024: 19.9MMay 2024: 21.3MMay 2024Aug 2024: 21.7MOct 2024: 21.8MOct 2024Feb 2025: 22.1MApr 2025: 22.2MApr 2025Aug 2025: 22.3MOct 2025: 22.7MOct 2025Feb 2026: 22.9MMay 2026: 23.1MMay 2026Jul 2026: 23.1MOct 2026: 23.2MOct 202623.2M
Show the numbers
Shares outstanding
Feb 202318.1M
May 202318.3M
Aug 202318.5M
Nov 202319.7M
Feb 202419.9M
May 202421.3M
Aug 202421.7M
Oct 202421.8M
Feb 202522.1M
Apr 202522.2M
Aug 202522.3M
Oct 202522.7M
Feb 202622.9M
May 202623.1M
Jul 202623.1M
Oct 202623.2M

The share count is up +2.3% in a year, so each share is a slightly smaller slice of the company. What dilution means.

Insider trades

Insider buys, 12 months5$35M
Insider sales, 12 months192$73.9M, 171 planned in advance

Bought or sold on the open market

DateWhoWhatSharesValueFiling
Nov 6, 2026Bros. Advisors LP (+5 joint filers) Baker
Director
Bought on the market
3 trades that day
76.1K$29.3MForm 4
Nov 6, 2026Shannon T Kelley
General Counsel
Sold on the market (planned)1.1K$431KForm 4
Nov 4, 2026Bros. Advisors LP (+5 joint filers) Baker
Director
Bought on the market
2 trades that day
15.7K$5.76MForm 4
Sep 11, 2026William John Sibold
President and CEO, Director
Sold on the market (planned)
10 trades that day
5.2K$2.83MForm 4
Sep 9, 2026William John Sibold
President and CEO, Director
Sold on the market (planned)
14 trades that day
6.4K$3.41MForm 4
Aug 17, 2026Shannon T Kelley
General Counsel
Sold on the market664$342KForm 4
Jul 20, 2026William John Sibold
President and CEO, Director
Sold on the market
10 trades that day
2.5K$1.37MForm 4
Jun 1, 2026David Soergel
Chief Medical Officer
Sold on the market (planned)1K$517KForm 4
May 22, 2026Richard S Levy
Director
Sold on the market (planned)
12 trades that day
5.7K$2.93MForm 4
May 18, 2026David Soergel
Chief Medical Officer
Sold on the market844$435KForm 4
Mar 6, 2026Mardi Dier
EVP and CFO
Sold on the market (planned)
12 trades that day
2K$854KForm 4
Mar 6, 2026William John Sibold
President and CEO, Director
Sold on the market1.7K$718KForm 4
Mar 6, 2026Shannon T Kelley
General Counsel
Sold on the market360$155KForm 4
Mar 6, 2026Carole Huntsman
Chief Commercial Officer
Sold on the market419$181KForm 4
Mar 6, 2026Rebecca Taub
Director
Sold on the market491$212KForm 4
Everything else: grants, option exercises, tax withholding (24)
DateWhoWhatSharesValueFiling
Aug 15, 2026John C Reed
Director
Grant or award647n/aForm 4
Jul 17, 2026William John Sibold
President and CEO, Director
Exercised options50Kn/aForm 4
Jun 17, 2026Rebecca Taub
Director
Grant or award454n/aForm 4
Jun 17, 2026Richard S Levy
Director
Grant or award454n/aForm 4
Jun 17, 2026Jacqualyn A Fouse
Director
Grant or award454n/aForm 4
Jun 17, 2026James M Daly
Director
Grant or award454n/aForm 4
Jun 17, 2026Daniel J. Brennan
Director
Grant or award404n/aForm 4
Jun 17, 2026Bros. Advisors LP (+5 joint filers) Baker
Director
Grant or award
2 trades that day
1.8Kn/aForm 4
Mar 4, 2026Mardi Dier
EVP and CFO
Grant or award (planned)5.2Kn/aForm 4
Mar 4, 2026William John Sibold
President and CEO, Director
Grant or award15Kn/aForm 4
Mar 4, 2026Shannon T Kelley
General Counsel
Grant or award4Kn/aForm 4
Mar 4, 2026Carole Huntsman
Chief Commercial Officer
Grant or award4Kn/aForm 4
Mar 4, 2026David Soergel
Chief Medical Officer
Grant or award4.4Kn/aForm 4
Feb 23, 2026Richard S Levy
Director
Exercised options2.5K$18.4KForm 4
Jan 26, 2026Richard S Levy
Director
Exercised options4K$65.8KForm 4
Jan 15, 2026Rita Thakkar
Chief Accounting Officer
Grant or award2.4Kn/aForm 4
Jan 9, 2026Paul A Friedman
Director
Exercised options (planned)
2 trades that day
24.8K$392KForm 4
Jan 9, 2026Rebecca Taub
Director
Exercised options (planned)
2 trades that day
18.7K$295KForm 4
Dec 10, 2025Paul A Friedman
Director
Exercised options (planned)24.8K$392KForm 4
Dec 10, 2025Rebecca Taub
Director
Exercised options (planned)18.7K$295KForm 4
Dec 10, 2025Rebecca Taub
Director
Gift (planned)5.5Kn/aForm 4
Dec 3, 2025William John Sibold
President and CEO, Director
Exercised options50Kn/aForm 4
Dec 2, 2025Mardi Dier
EVP and CFO
Exercised options (planned)4.2K$1.05MForm 4
Nov 13, 2025Richard S Levy
Director
Exercised options (planned)
2 trades that day
8.5K$117KForm 4

An insider buying with their own money is a stronger signal than a sale: people sell for taxes, houses and diversification. "Planned" sales were scheduled months ahead under a 10b5-1 plan. Source: SEC Form 4.

Famous investors who own it

None of the 18 famous investors I track owned MDGL at their last 13F. Who I track.

Failed trades

Failed trades (fails to deliver) shares that weren't delivered on time when a trade settled
May 14: 97May 26: 268Jun 5: 363Jun 5Jun 8: 2KJun 12: 5.9KJun 15: 2.4KJun 15Jun 26: 2.1KJun 29: 209KJun 30: 208KJun 30Jul 8: 1.7KJul 10: 6.2KJul 20: 49Jul 20Jul 27: 143Aug 3: 248Aug 4: 18KAug 4Aug 10: 3.6KAug 12: 21Aug 18: 22Aug 18Aug 20: 253Aug 28: 1.2KSep 15: 3Sep 15Oct 7: 32.7KOct 8: 22Oct 9: 22Oct 922
Show the numbers
Failed trades (fails to deliver)
May 1497
May 26268
Jun 5363
Jun 82K
Jun 125.9K
Jun 152.4K
Jun 262.1K
Jun 29209K
Jun 30208K
Jul 81.7K
Jul 106.2K
Jul 2049
Jul 27143
Aug 3248
Aug 418K
Aug 103.6K
Aug 1221
Aug 1822
Aug 20253
Aug 281.2K
Sep 153
Oct 732.7K
Oct 822
Oct 922

From the SEC's fails-to-deliver data, which runs two to four weeks behind. A spike can mean heavy short selling or just back-office delays; it isn't proof of anything on its own. Short interest isn't shown: FINRA's terms don't allow republishing it.

Share offerings

Selling new shares dilutes current owners. A "shelf" is permission to sell later; a 424B5 usually means a sale is actually happening.

What they told the SEC, in plain English

Every 8-K (the report a company files when something big happens) in the last two years. Red ones are worth a closer look: auditor changes, restatements, late reports, listing problems.

What changed in the latest annual report

Comparing the risk factors in the 10-K filed Feb 19, 2026 with the one filed Feb 26, 2025: 9 new and 4 removed, out of 76.

New this year

  • If we are unable to obtain or maintain adequate coverage and reimbursement from government or third-party payors for Rezdiffra or, if approved, any other product candidates, our prospects for generating revenue may be adversely affected.
  • Federal legislative and regulatory efforts to implement reference pricing or most-favored-nation pricing models could impact our product revenues and harm our business.
  • Rezdiffra was approved for treatment in a limited population of patients with MASH with moderate to advanced liver fibrosis, and additional clinical trials and regulatory applications will be required to expand its indication. We may not be successful in these trials or in obtaining such…
  • EU pricing and reimbursement regulations may materially affect our ability to market and receive coverage for Rezdiffra in the EU Member States.
  • We may in the future conduct certain clinical trials for our product candidates outside of the U.S. However, the FDA may not accept data from such trials, in which case our development plans will be delayed, which could materially harm our business.
  • Using specialty distributors to market and sell Rezdiffra in certain jurisdictions outside of the United States subjects us to certain risks.
  • Anti-takeover provisions in our restated certificate of incorporation (our "Charter"), our Restated Bylaws (our "Bylaws") and under Delaware law could make an acquisition of our company, which may be beneficial to our stockholders, more difficult and may prevent attempts by our stockholders to…
  • Taxing authorities could challenge our historical and future tax positions or our allocation of taxable income among our subsidiaries and we may incur additional tax liabilities.
  • Volatility in foreign currency exchange rates could have a material adverse effect on our operating results.
Dropped from last year (4)
  • We may become subject to unfavorable pricing regulations or third-party coverage and reimbursement policies, which would harm our business.
  • Governments outside the United States tend to impose strict price controls, which may adversely affect our revenues, if any.
  • We may enter into out-licenses or pursue collaborative relationships with entities in foreign jurisdictions outside of the United States and Europe.
  • A small number of our stockholders beneficially own a substantial amount of our outstanding common stock and may be deemed to have substantial control over us; therefore, your ability to influence corporate matters may be limited.

Matched by each risk's headline, so a reworded risk can show up as new. This year's report · last year's.

Government contracts

$65.3K in federal contract money over the last 12 months, across 2 awards and changes.

DateAgencyWhat forAmount
Apr 3, 2026Department of Veterans AffairsREZDIFFRA 80 MG$35.6K
Jun 5, 2026Department of Veterans AffairsREZDIFFRA 80 MG$29.7K

From USAspending.gov. Amounts are money the government committed, which can be cut later.

Search inside Madrigal Pharmaceuticals's filings

Opens the SEC's own full-text search in a new tab, limited to MDGL. Every MDGL filing on EDGAR.