Stocks·NASDAQ:MDGL
Madrigal Pharmaceuticals (MDGL)
My take
No average analyst target in this video.
Every video where I mention MDGL
The last 12 months
- Nov 3, 202610-QQuarterly report
- Nov 3, 20268-KReleased quarterly results
- Aug 12, 20268-KExecutive or board change; Shared information with investors
- Jul 30, 202610-QQuarterly report
- Jul 30, 20268-KReleased quarterly results
- Jun 17, 2026S-8Registered shares for employee stock plans
- Jun 17, 20268-KExecutive or board change; Shareholder vote results
- May 6, 202610-QQuarterly report
- May 6, 20268-KReleased quarterly results
- Apr 28, 20268-KExecutive or board change
- Feb 19, 202610-KAnnual report
- Feb 19, 20268-KReleased quarterly results
- Jan 30, 20268-KSigned a major agreement
- Dec 11, 20258-KExecutive or board change
Cash runway: about 68 months. Madrigal Pharmaceuticals had $961M in cash and short-term investments on Sep 30, 2026 and burned $169M of free cash flow over the 12 months before that, about $42.2M a quarter. Divide one by the other and that's the runway, if nothing changes.
My math, not the company's. It doesn't count money raised after Sep 30, 2026 (check the Filings tab for offerings), credit lines, or plans to cut spending.
Show the numbers
| Revenue by year | |
|---|---|
| 2017 | $0 |
| 2018 | $0 |
| 2019 | $0 |
| 2020 | $0 |
| 2021 | $0 |
| 2022 | $0 |
| 2023 | $0 |
| 2024 | $180M |
| 2025 | $958M |
Show the numbers
| Revenue by quarter | |
|---|---|
| Q4 23 | $0 |
| Q1 24 | $0 |
| Q2 24 | $14.6M |
| Q3 24 | $62.2M |
| Q4 24 | $103M |
| Q1 25 | $137M |
| Q2 25 | $213M |
| Q3 25 | $287M |
| Q4 25 | $321M |
| Q1 26 | $311M |
| Q2 26 | $364M |
| Q3 26 | $431M |
Show the numbers
| Operating income (loss) by year | |
|---|---|
| 2016 | -$25.2M |
| 2017 | -$32.1M |
| 2018 | -$40.7M |
| 2019 | -$95M |
| 2020 | -$207M |
| 2021 | -$242M |
| 2022 | -$294M |
| 2023 | -$380M |
| 2024 | -$498M |
| 2025 | -$300M |
Show the numbers
| Free cash flow by year | |
|---|---|
| 2016 | -$17.6M |
| 2017 | -$22.4M |
| 2018 | -$25.5M |
| 2019 | -$41.8M |
| 2020 | -$158M |
| 2021 | -$184M |
| 2022 | -$225M |
| 2023 | -$326M |
| 2024 | -$457M |
| 2025 | -$190M |
Cash and short-term investmentsDebt
Show the numbers
| Cash and short-term investments | Debt | |
|---|---|---|
| 2016 | $40.5M | n/a |
| 2017 | $192M | n/a |
| 2018 | $484M | n/a |
| 2019 | $439M | n/a |
| 2020 | $284M | n/a |
| 2021 | $270M | $0 |
| 2022 | $359M | $69.7M |
| 2023 | $634M | $115M |
| 2024 | $926M | $118M |
| 2025 | $984M | $340M |
Stock-based pay to employeesSpent buying back shares
Show the numbers
| Stock-based pay to employees | Spent buying back shares | |
|---|---|---|
| 2020 | $20.7M | $0 |
| 2021 | $26.9M | $0 |
| 2022 | $31.6M | $0 |
| 2023 | $49.7M | $0 |
| 2024 | $79.9M | $0 |
| 2025 | $98.1M | $0 |
If buybacks are smaller than stock pay, the buyback isn't shrinking the share count; it's soaking up shares handed to employees.
Compare MDGL with other stocks →
From the company's own SEC filings via SEC EDGAR, latest period ended Sep 30, 2026. Numbers can be restated later. Not investment advice.
Dilution
Show the numbers
| Shares outstanding | |
|---|---|
| Feb 2023 | 18.1M |
| May 2023 | 18.3M |
| Aug 2023 | 18.5M |
| Nov 2023 | 19.7M |
| Feb 2024 | 19.9M |
| May 2024 | 21.3M |
| Aug 2024 | 21.7M |
| Oct 2024 | 21.8M |
| Feb 2025 | 22.1M |
| Apr 2025 | 22.2M |
| Aug 2025 | 22.3M |
| Oct 2025 | 22.7M |
| Feb 2026 | 22.9M |
| May 2026 | 23.1M |
| Jul 2026 | 23.1M |
| Oct 2026 | 23.2M |
The share count is up +2.3% in a year, so each share is a slightly smaller slice of the company. What dilution means.
Insider trades
Bought or sold on the open market
| Date | Who | What | Shares | Value | Filing |
|---|---|---|---|---|---|
| Nov 6, 2026 | Bros. Advisors LP (+5 joint filers) Baker Director | Bought on the market 3 trades that day | 76.1K | $29.3M | Form 4 |
| Nov 6, 2026 | Shannon T Kelley General Counsel | Sold on the market (planned) | 1.1K | $431K | Form 4 |
| Nov 4, 2026 | Bros. Advisors LP (+5 joint filers) Baker Director | Bought on the market 2 trades that day | 15.7K | $5.76M | Form 4 |
| Sep 11, 2026 | William John Sibold President and CEO, Director | Sold on the market (planned) 10 trades that day | 5.2K | $2.83M | Form 4 |
| Sep 9, 2026 | William John Sibold President and CEO, Director | Sold on the market (planned) 14 trades that day | 6.4K | $3.41M | Form 4 |
| Aug 17, 2026 | Shannon T Kelley General Counsel | Sold on the market | 664 | $342K | Form 4 |
| Jul 20, 2026 | William John Sibold President and CEO, Director | Sold on the market 10 trades that day | 2.5K | $1.37M | Form 4 |
| Jun 1, 2026 | David Soergel Chief Medical Officer | Sold on the market (planned) | 1K | $517K | Form 4 |
| May 22, 2026 | Richard S Levy Director | Sold on the market (planned) 12 trades that day | 5.7K | $2.93M | Form 4 |
| May 18, 2026 | David Soergel Chief Medical Officer | Sold on the market | 844 | $435K | Form 4 |
| Mar 6, 2026 | Mardi Dier EVP and CFO | Sold on the market (planned) 12 trades that day | 2K | $854K | Form 4 |
| Mar 6, 2026 | William John Sibold President and CEO, Director | Sold on the market | 1.7K | $718K | Form 4 |
| Mar 6, 2026 | Shannon T Kelley General Counsel | Sold on the market | 360 | $155K | Form 4 |
| Mar 6, 2026 | Carole Huntsman Chief Commercial Officer | Sold on the market | 419 | $181K | Form 4 |
| Mar 6, 2026 | Rebecca Taub Director | Sold on the market | 491 | $212K | Form 4 |
Everything else: grants, option exercises, tax withholding (24)
| Date | Who | What | Shares | Value | Filing |
|---|---|---|---|---|---|
| Aug 15, 2026 | John C Reed Director | Grant or award | 647 | n/a | Form 4 |
| Jul 17, 2026 | William John Sibold President and CEO, Director | Exercised options | 50K | n/a | Form 4 |
| Jun 17, 2026 | Rebecca Taub Director | Grant or award | 454 | n/a | Form 4 |
| Jun 17, 2026 | Richard S Levy Director | Grant or award | 454 | n/a | Form 4 |
| Jun 17, 2026 | Jacqualyn A Fouse Director | Grant or award | 454 | n/a | Form 4 |
| Jun 17, 2026 | James M Daly Director | Grant or award | 454 | n/a | Form 4 |
| Jun 17, 2026 | Daniel J. Brennan Director | Grant or award | 404 | n/a | Form 4 |
| Jun 17, 2026 | Bros. Advisors LP (+5 joint filers) Baker Director | Grant or award 2 trades that day | 1.8K | n/a | Form 4 |
| Mar 4, 2026 | Mardi Dier EVP and CFO | Grant or award (planned) | 5.2K | n/a | Form 4 |
| Mar 4, 2026 | William John Sibold President and CEO, Director | Grant or award | 15K | n/a | Form 4 |
| Mar 4, 2026 | Shannon T Kelley General Counsel | Grant or award | 4K | n/a | Form 4 |
| Mar 4, 2026 | Carole Huntsman Chief Commercial Officer | Grant or award | 4K | n/a | Form 4 |
| Mar 4, 2026 | David Soergel Chief Medical Officer | Grant or award | 4.4K | n/a | Form 4 |
| Feb 23, 2026 | Richard S Levy Director | Exercised options | 2.5K | $18.4K | Form 4 |
| Jan 26, 2026 | Richard S Levy Director | Exercised options | 4K | $65.8K | Form 4 |
| Jan 15, 2026 | Rita Thakkar Chief Accounting Officer | Grant or award | 2.4K | n/a | Form 4 |
| Jan 9, 2026 | Paul A Friedman Director | Exercised options (planned) 2 trades that day | 24.8K | $392K | Form 4 |
| Jan 9, 2026 | Rebecca Taub Director | Exercised options (planned) 2 trades that day | 18.7K | $295K | Form 4 |
| Dec 10, 2025 | Paul A Friedman Director | Exercised options (planned) | 24.8K | $392K | Form 4 |
| Dec 10, 2025 | Rebecca Taub Director | Exercised options (planned) | 18.7K | $295K | Form 4 |
| Dec 10, 2025 | Rebecca Taub Director | Gift (planned) | 5.5K | n/a | Form 4 |
| Dec 3, 2025 | William John Sibold President and CEO, Director | Exercised options | 50K | n/a | Form 4 |
| Dec 2, 2025 | Mardi Dier EVP and CFO | Exercised options (planned) | 4.2K | $1.05M | Form 4 |
| Nov 13, 2025 | Richard S Levy Director | Exercised options (planned) 2 trades that day | 8.5K | $117K | Form 4 |
An insider buying with their own money is a stronger signal than a sale: people sell for taxes, houses and diversification. "Planned" sales were scheduled months ahead under a 10b5-1 plan. Source: SEC Form 4.
Famous investors who own it
None of the 18 famous investors I track owned MDGL at their last 13F. Who I track.
Failed trades
Show the numbers
| Failed trades (fails to deliver) | |
|---|---|
| May 14 | 97 |
| May 26 | 268 |
| Jun 5 | 363 |
| Jun 8 | 2K |
| Jun 12 | 5.9K |
| Jun 15 | 2.4K |
| Jun 26 | 2.1K |
| Jun 29 | 209K |
| Jun 30 | 208K |
| Jul 8 | 1.7K |
| Jul 10 | 6.2K |
| Jul 20 | 49 |
| Jul 27 | 143 |
| Aug 3 | 248 |
| Aug 4 | 18K |
| Aug 10 | 3.6K |
| Aug 12 | 21 |
| Aug 18 | 22 |
| Aug 20 | 253 |
| Aug 28 | 1.2K |
| Sep 15 | 3 |
| Oct 7 | 32.7K |
| Oct 8 | 22 |
| Oct 9 | 22 |
From the SEC's fails-to-deliver data, which runs two to four weeks behind. A spike can mean heavy short selling or just back-office delays; it isn't proof of anything on its own. Short interest isn't shown: FINRA's terms don't allow republishing it.
Share offerings
Selling new shares dilutes current owners. A "shelf" is permission to sell later; a 424B5 usually means a sale is actually happening.
- Jun 17, 2026S-8Registered shares for employee stock plans
- Sep 11, 2025S-8Registered shares for employee stock plans
- Jun 20, 2025S-8Registered shares for employee stock plans
What they told the SEC, in plain English
Every 8-K (the report a company files when something big happens) in the last two years. Red ones are worth a closer look: auditor changes, restatements, late reports, listing problems.
- Nov 3, 20268-KReleased quarterly results
- Aug 12, 20268-KExecutive or board change; Shared information with investors
- Jul 30, 20268-KReleased quarterly results
- Jun 17, 20268-KExecutive or board change; Shareholder vote results
- May 6, 20268-KReleased quarterly results
- Apr 28, 20268-KExecutive or board change
- Feb 19, 20268-KReleased quarterly results
- Jan 30, 20268-KSigned a major agreement
- Dec 11, 20258-KExecutive or board change
- Nov 4, 20258-KReleased quarterly results
- Aug 5, 20258-KReleased quarterly results
- Jul 30, 20258-KShared information with investors
- Jul 22, 20258-KSigned a major agreement; Ended a major agreement; Took on new debt; Shared information with investors
- Jun 20, 20258-KShareholder vote results
- May 1, 20258-KReleased quarterly results
- Apr 17, 20258-KExecutive or board change
- Mar 11, 20258-KExecutive or board change; Shared information with investors
- Feb 26, 20258-KReleased quarterly results
- Jan 13, 20258-KReleased quarterly results
- Nov 14, 2024SC 13GAn investor reported a 5%+ stake
What changed in the latest annual report
Comparing the risk factors in the 10-K filed Feb 19, 2026 with the one filed Feb 26, 2025: 9 new and 4 removed, out of 76.
New this year
- If we are unable to obtain or maintain adequate coverage and reimbursement from government or third-party payors for Rezdiffra or, if approved, any other product candidates, our prospects for generating revenue may be adversely affected.
- Federal legislative and regulatory efforts to implement reference pricing or most-favored-nation pricing models could impact our product revenues and harm our business.
- Rezdiffra was approved for treatment in a limited population of patients with MASH with moderate to advanced liver fibrosis, and additional clinical trials and regulatory applications will be required to expand its indication. We may not be successful in these trials or in obtaining such…
- EU pricing and reimbursement regulations may materially affect our ability to market and receive coverage for Rezdiffra in the EU Member States.
- We may in the future conduct certain clinical trials for our product candidates outside of the U.S. However, the FDA may not accept data from such trials, in which case our development plans will be delayed, which could materially harm our business.
- Using specialty distributors to market and sell Rezdiffra in certain jurisdictions outside of the United States subjects us to certain risks.
- Anti-takeover provisions in our restated certificate of incorporation (our "Charter"), our Restated Bylaws (our "Bylaws") and under Delaware law could make an acquisition of our company, which may be beneficial to our stockholders, more difficult and may prevent attempts by our stockholders to…
- Taxing authorities could challenge our historical and future tax positions or our allocation of taxable income among our subsidiaries and we may incur additional tax liabilities.
- Volatility in foreign currency exchange rates could have a material adverse effect on our operating results.
Dropped from last year (4)
- We may become subject to unfavorable pricing regulations or third-party coverage and reimbursement policies, which would harm our business.
- Governments outside the United States tend to impose strict price controls, which may adversely affect our revenues, if any.
- We may enter into out-licenses or pursue collaborative relationships with entities in foreign jurisdictions outside of the United States and Europe.
- A small number of our stockholders beneficially own a substantial amount of our outstanding common stock and may be deemed to have substantial control over us; therefore, your ability to influence corporate matters may be limited.
Matched by each risk's headline, so a reworded risk can show up as new. This year's report · last year's.
Government contracts
$65.3K in federal contract money over the last 12 months, across 2 awards and changes.
| Date | Agency | What for | Amount |
|---|---|---|---|
| Apr 3, 2026 | Department of Veterans Affairs | REZDIFFRA 80 MG | $35.6K |
| Jun 5, 2026 | Department of Veterans Affairs | REZDIFFRA 80 MG | $29.7K |
From USAspending.gov. Amounts are money the government committed, which can be cut later.
Search inside Madrigal Pharmaceuticals's filings
Opens the SEC's own full-text search in a new tab, limited to MDGL. Every MDGL filing on EDGAR.